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This illuminating text/reference presents a review of the key aspects of the modeling and simulation (M&S) life cycle, and examines the challenges of M&S in different application areas. The authoritative work offers valuable perspectives on the future of research in M&S, and its role in engineering complex systems. Topics and features: reviews the challenges of M&S for urban infrastructure, healthcare delivery, automated vehicle manufacturing, deep space missions, and acquisitions enterprise; outlines research issues relating to conceptual modeling, covering the development of explicit and unambiguous models, communication and decision-making, and architecture and services; considers key computational challenges in the execution of simulation models, in order to best exploit emerging computing platforms and technologies; examines efforts to understand and manage uncertainty inherent in M&S processes, and how these can be unified under a consistent theoretical and p
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