[PDF] Coursera - Virology I: How Viruses Work

ISBN: 50a9dde091

Category: Tutorial


Posted on 2017-11-07, by luongquocchinh.

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Author: Coursera | Category: Video (tutorials, how-to, etc.) | Language: English | ISBN: 50a9dde091b94f35bf5e5a35124d31fb |

Description: Coursera - Virology I: How Viruses Work English | 2013 | mp4 | VP80 960x540 | Vorbis 2 ch | 2 hrs 8 min | pdf | 3.72 GB eLearning Introductory virology course emphasizing the common reactions that must be completed by all viruses for successful reproduction within a host cell. This introductory virology course emphasizes the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles are presented with examples drawn from a set of representative animal and human viruses, although selected bacterial viruses will be discussed. This offering has been a top-ten iTunes U Course in sciences pretty much since its release in 2012, with over 80,000 subscriptions. The course will be ported to the Coursera platform in two parts and will allow interested online students to take the course as a cohort for the first time. Course Syllabus Week 1 - Welcome to virology - What is a virus? - Viruses then and now Week 2 - The infectious cycle - Assay of viral infectivity - Measurement of virions and their components - Revolutionary methods - One-step growth cycle Week 3 - The Baltimore scheme - DNA virus genomes - RNA virus genomes - Viral genetics Week 4 - Structure - The tools of structural virology - Helical symmetry - Icosahedral symmetry - Enveloped virions - Complex virions Week 5 - Attachment to cells - Entry into cells - Acid-catalyzed fusion - A new paradigm for entry - Entry of non-enveloped virions - Entering the nucleus Week 6 - Viral RNA synthesis - RNA polymerization - Plus strand RNA synthesis - Negative strand RNA synthesis - RNA synthesis of dsRNA genomes - RNA synthesis as a source of diversity Week 7 - DNA basics - Lessons from SV40 - Priming via DNA or protein - Viral origins - Big DNA viruses - Regulation of DNA synthesis Week 8 - Transcription - Initiation of transcription - Viral transcription regulation - Capping and polyadenylation - Pre-mRNA splicing Week 9 - Reverse transcriptase - Retroviruses - Reverse transcription - Integration - The provirus - Hepatitis B virus Week 10 - End-dependent initiation of protein synthesis - Other decoding mechanisms - One mRNA, one protein? - Maximizing coding capacity of the viral genome - Regulation of translation: eIF2alpha - How viruses regulate cell translation - MicroRNAs Week 11 - Principles of virion assembly - Getting to the right place - Making sub-assemblies - Concerted assembly: Budding - Genome packaging - Acquisition of an envelope and egress Recommended Background Two semesters of a rigorous, molecularly-oriented introductory biology course.

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