Metabolomics by In Vivo NMR

Metabolism By In Vivo NMR reviews and extends the experimental and theoretical reports concerning in vivo NMR, a pioneering approach that offers versatile new ways of studying metabolic pathways. Perfectly timed to coincide with recent findings that demonstrate the novelty and strength of this approach, the book covers recent applications in biochemistry, medicine, and psychology; in vivo NMR techniques; MCA; glucose metabolism focusing on glycogen; the value of muscle glycogen measurements in exercise; and much more. This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders Novel and potentially controversial Will inspire future research directions. Content: Chapter 1 Introduction (pages 1-5): Robert G. ShulmanChapter 2 In Vivo NMR Spectroscopy - Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations (pages 7-29): Robin de GraafChapter 3 Metabolic Control Analysis for the NMR Spectroscopist (pages 31-44): David A. FellChapter 4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes (pages 45-57): Gerald I. Shulman and Douglas L. RothmanChapter 5 Phosphorylation of Allosteric Enzymes Can Serve Homeostasis rather than Control Flux: The Example of Glycogen Synthase (pages 59-71): James R.A. Schafer, David A. Fell, Douglas L. Rothman and Robert G. ShulmanChapter 6 Regulation of Glycogen Metabolism in Muscle during Exercise (pages 73-86): Thomas B. PriceChapter 7 13C NMR Studies of Heart Glycogen Metabolism (pages 87-102): Maren R. Laughlin, Douglas L. Rothman and Robert G. ShulmanChapter 8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction (pages 103-123): Thomas JueChapter 9 Lactate, Glycogen and Fatigue (pages 125-135): Robert G. Shulman and Douglas L. RothmanChapter 10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty (pages 137-148): Jan den Hollander and Robert G. ShulmanChapter 11 Trehalose Energetics in Yeast Spores (pages 149-158): Robert G. Shulman and Jan den HollanderChapter 12 Metabolic Networks in the Liver by 2H and 13C NMR (pages 159-174): A. Dean Sherry and Craig R. MalloyChapter 13 Summarized Reflections on Metabolism (pages 175-184): Robert G. Shulman, Douglas L. Rothman and James R. A. Schafer

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