Mechanisms of Drug Resistance in Epilepsy: Lessons from Oncology - No. 243

Mechanisms of Drug Resistance in Epilepsy: Lessons from Oncology - No. 243 (Novartis Foundation Symposia)

Publisher: Wiley
Number Of Pages: 254
Publication Date: 2002-05-13
Sales Rank: 3658052
ISBN / ASIN: 047084146X
EAN: 9780470841464
Binding: Hardcover
Manufacturer: Wiley
Studio: Wiley

Drug resistance in epilepsy is an important clinical problem. About 200f patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.

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