[share_ebook] The Dynamic Of Glucose-Insulin Endocrine Metabolic Regulatory System: A System Dynamics Approach

Description

THE DYNAMIC OF GLUCOSE-INSULIN ENDOCRINE
METABOLIC REGULATORY SYSTEM: A SYSTEM DYNAMICS
APPROACH
By
Fadhl Mohammed Ahmed Al-Akwaa
fadlyemen@hotmail.com
A Thesis Submitted to the
Faculty of Engineering at Cairo University
In partial Fulfillment of the
Requirements for the Degree of
MASTER OF SCIENCE
In
SYSTEMS & BIOMEDICAL ENGINEERING
FACULTY OF ENGINEERING, CAIRO UNIVERSITY
GIZA, EGYPT
MARCH 2006

Diabetes mellitus is a disease in the glucose-insulin endocrine metabolic
regulatory system, in which the pancreas either does not release insulin or does not
properly use insulin to uptake glucose in the plasma, which is referred as
hyperglycemia. Complications of diabetes mellitus include retinopathy, nephropathy,
peripheral neuropathy and blindness.
Diabetes mellitus is one of the worst diseases with respect to size of the affected
Population. According to the data published by the Egyptian Ministry of Health and
Population and the United States Agency for International Development, the total
number of persons with diagnosed and undiagnosed diabetes in Egypt will increase
from 3.24 million in 1995 to 3.80 million in 2000 and to 8.80 million by the year
2025.
The economic impact of diabetes is staggering Total costs of diabetes in the U.S. in
2002 were estimated to be $132 billion.
Due to the large population of diabetes patients in the world and the big health
expenses, many researchers are motivated to study the glucose-insulin endocrine
metabolic regulatory system so that we can better understand how the mechanism
functions, what cause the dysfunctions of the system, how to detect the onset of the
either type of diabetes.
The purpose of this study is to model the dynamic of the short-term glucose
regulatory system (GRS) in man and its hormonal regulation by considering all the
feedback loops which are responsible of controlling the glucose metabolism in man.
The model proposed in this work used the system dynamics (SD) approach which was
designed for studying complex systems. This SD model consists of twenty-three
negative (balance) loops and six compartments. The model was validated during wide
range of clinical test inputs, to be sure that this model accurately represents the really
endocrine system.
Understanding the mechanism underlying glucose-insulin oscillations and
determination of the origin of the glucose–insulin levels oscillations is another
purpose of this model.
Other applications for this model also have been explored.

Disclaimer:
Contents of this page are indexed from the Internet. All actions are under your responsability. Email us to report illegal contents or external links and we'll remove them immediately.

Download links for "[share_ebook] The Dynamic Of Glucose-Insulin Endocrine Metabolic Regulatory System: A System Dynamics Approach":



How to Download
You may need eMule or Bittorrent to download ebook torrents or emule links.

Report Dead Link
Please leave a comment to report dead links, so that someone else may update new links.

1. Ebooks list page : 1595
2. Dynamic System Reconfiguration in Heterogeneous Platforms: The MORPHEUS Approach
3. Your Body: How It Works 5. Endocrine System
4. Your Body: How It Works - The Endocrine System (2004)
5. The Endocrine System (The Human Body-How It Works)
6. [share_ebook] 000-918: System Administration for IBM Informix Dynamic Server V11
7. Insulin Resistance: the Metabolic Syndrome X (Contemporary Endocrinology)
8. Insulin Resistance: the Metabolic Syndrome X (Contemporary Endocrinology)
9. [share_ebook] Journal: Experimental of Dynamic Characteristic of an Exhaust System
10. William J. Kraemer, Alan D. Rogol - The Endocrine System in Sports and Exercise (Repost)
11. Neurosteriods: A New Regulatory Function in the Nervous System (US$101.26)
12. [share_ebook] Advances in Artificial Economics: The Economy as a Complex Dynamic System
13. Meyler's Side Effects of Endocrine and Metabolic Drugs
14. Emergency Medicine Clinics of NA - Endocrine and Metabolic Emerg
15. [share_ebook] Computational Fluid Dynamics (Vol. 1)
16. [share_ebook] Computational Fluid Dynamics (Vol. 2)